Category: Science, Physics, and Philosophy of Science

  • Dr Michael Levin (@drmichaellevin), (All); Great Paper. Thanks for open access.

    Dr Michael Levin (@drmichaellevin), (All);

    Great Paper. Thanks for open access. (Really.)

    And of course I agree that Dr Levin’s work, demonstrating the influence of electromagnetic charge, which serves to illustrate that evolution not only finds a way, but it finds every way possible to assist life evolve complexity. This added dimension of causality caused me to update my own work.

    However, this paper gave me pause. And it’s not necessarily negative feedback about this paper, which is correct, even given Michael’s tendency to apply the utility of professorial attention-seeking of students (and readers) by implication of wonder to that which would better be stated without it. πŸ˜‰

    Michael Levin (@drmichaellevin) from Tufts has just published, Andrew Budson (@abudson) from BU and Harvard has just published. And I could list a dozen more attempts at exposition in popular science – most of which are tragically embarassing. But Jeff Hawkins (@JeffCHawkins) at Redwood Center for Theoretical Neuroscience and founder of Numenta (and inventor of the Palm Pilot) has been working with these ideas for almost two decades. And while I started writing neural networks on “ancient iron” using assembly language, I’d say most of the innovation that I rely on when I teach the foundations of cognition is based upon his synthesis of neuroscience.

    The only rather fascinating aspect of LLM’s is the use of brute force, using massive volumes of text, and massively expensive computing power (and energy), to make use of the ordinary grammar, consisting of (a) the first principle of the universe’s evolution: continuous recursive disambiguation of disorder into order, into (b) continuous recursive organization of bodily movements, (c) into continuous recursive disambiguation of navigational way-finding, (d) into continuous recursive disambiguation of thinking (e) into continuous recursive disambiguation into speech as Chomsky’s ‘universal grammar’. A process itself which consists of evolutionary computation of complexity by continuous recursive disambiguation of disorder into order. πŸ˜‰

    So it turns out that phrases, sentences, paragraphs, narratives, arguments, and proofs, are, by their grammar (rules of continuous recursive disambiguation) and thus their organization of references alone, in sufficient volume, are, specifications for actors, objects, spaces, backgrounds, possible actions and navigation through them: Episodes of all scales – whether concrete, imaginary, or abstract.

    But why does each generation of academics have to ‘rediscover’ that which we knew one or two generations before, then claim it’s a novel discovery?

    And what does that tell us about our education, disciplines, and institutions?

    In the eighties and nineties those of us who worked on the application of neuroscience and cognitive science to our futile attempts at artificial intelligence given the paucity of available memory, storage, and computing power explained the development of memory as an economy of connectivity within the biological ecology of the body. And when explaining memory’s behavior we used the development of traffic patterns before during and after the mass introduction of motor vehicles.

    I mean, we wrote mathematics, software, simulations, and games to illustrate it. Our problem, since the AI winter of the 1980s, which I was a part of, has always been hardware, and the remaining problem is still hardware – at least until the neuromorphic hardware revolution that’s been gradually developing out there produces a viable product – which will collapse the entire pre-calculated compute economy that’s animating the financial sector as we speak.

    Even Joscha Bach’s (@plinz) recent tweet “We finally have a theory of representation”, I find both true and odd, and a bit disturbing, because, between what we’ve understood by design of higher dimensional manifolds in mathematics, neural networks, simulations, and most obviously three dimensional real time simulations of the world (games), with their backgrounds, objects, actors, eye-head direction, body direction, movement direction, speed, bodily volume, and events, composed of triangles, surfaces, and reflectivity – and more so with hexagonal surface navigation: all of which are precisely what the hierarchy of the brain produces by precisely the same means: triangles. (and I’ll skip explaining why the universe has three dimensions plus time for the same reason – because that’s a whole different rat hole.)

    Around 2005 and 2006 I worked with team out of Microsoft one of whom had worked on the flight controls and navigation for the B2 Bomber which is impossible to fly without computer assistance, and another (like me) who was a quite sophisticated tools, software, and operating system architect. At that point, the use of graphics cards for vector processing had just been emerging. We discussed the model of the manifold, the use of threads of short and long term running agents (unlike LLM’s). We discussed the impact on Google’s search and revenue model.

    The problem was the amount of money necessary to produce both the software and the hardware. And I could not at that time ether (a) divert that much time from my existing businesses, (b) feel confident enough that we could raise that amount of money without producing a working model, which would take six months to a year full time by at least a small team. So we understood. … And we weren’t alone.

    As far as I know the most important information we’ve learned in neuroscience is the organization of the layers of the neocortex, the organization of micro columns, columns, how axons seek dendrites first through chemical signature and second though synchronicity, and the ‘insert, retrieve, update, delete cycle of axon, axon terminal, and dendritic computation’.

    After that all the valuable information that really mattered in understanding consciousness was the complexity of the hippocampal region in producing competition, coherence, parsimony, and indexing that could be used for long term association of such complex networks.

    And after that, and precisely the one thing – though likely quite obvious – that is left to explain, is ‘if that’s all neurons and nerves do, then what information are they transmitting that results in our conscious experience? “Memories of memories all the way down.”

    So the point I’m trying to make is perhaps less obvious: that in my work I continuously and disturbingly run across claims of insight and discovery that are from decades to generations if not centuries old.

    And that’s often because compartmentalization of disciplines has mandated ignorance, and the volume of nonsense publications obscures prior research in other fields.

    It’s far worse in technology because of the vast increases in the number of new people in each field on a regular basis has diluted knowledge to the point where every four years or so we produce a new generation of nerds who think they’re inventing, when all they are doing is compensating for – all too often – the absolutely horrific architecture of the browser and its means of running streams of text as software that never saw a compiler and for whom sufficient test cases to replace a complier are deleteriously costly.

    And don’t get me started on physics which is proud of it’s mathematical rigor without having the faintest idea what the foundations of mathematics consist of and the limits of mathematics vs computation and operation.

    At least in economics, we fail all the time, so we are extremely conscious of the limits of math. So physicists come to economics and tell us what we’re doing wrong. Mathematicians provide tools to physicists to enable them to do more. And those of us who work in the epistemology of such complex things, fail repeatedly to reform mathematics to take account for the superiority of computation and simulation in producing reducibility beyond that which mathematics cannot.

    After all the universe is discrete and mathematics … well, it doesn’t do that well. πŸ˜‰

    Cheers
    CD

    Michael Levin’s new book isn’t available yet.
    Publications ( long list )
    This Topic:
    https://t.co/djRYBirr6o
    Papers:
    https://t.co/J24lnUpjkx
    Preprints: https://t.co/pMYR7QxUDd

    Andrew Budson
    https://t.co/1Gr5VERopr

    Reply addressees: @drmichaellevin


    Source date (UTC): 2024-06-03 00:20:46 UTC

    Original post: https://twitter.com/i/web/status/1797423142895337472

    Replying to: https://twitter.com/i/web/status/1796477278169514472

  • DEFINITION: GENETIC LOAD Genetic load refers to the burden carried by a populati

    DEFINITION: GENETIC LOAD
    Genetic load refers to the burden carried by a population of organisms due to the accumulation of deleterious mutations, or the presence of less optimal gene variants, compared to some optimal genotype.

    This concept is crucial in the fields of genetics, evolutionary biology, and conservation biology because it has implications for the health, survival, and reproductive success of a species.

    TL’DR;
    Genetic load consists of the accumulation of genetic non-adaptation to domestication syndrome (neoteny), genetic mutation, and their combinations that result in variation from fitness, symmetry, neoteny, self regulation, and agency.

    The result in civil society, economics, and politics, is class variation, which consists of variation in the capacity to bear responsibility for self, private, and common over increasing periods of time.

    This is why there is so little class rotation. Genetics.

    TYPES OF GENETIC LOAD

    1. Mutational Load

    Definition: This is the genetic load imposed by harmful mutations that arise naturally through DNA replication errors or due to environmental factors. These mutations can reduce the fitness of individuals carrying them.

    Impact: Over time, new mutations may either be eliminated by natural selection if they are severely detrimental or accumulate in the population if they have only minor effects on fitness. The accumulation of many such slightly deleterious mutations can gradually reduce the overall fitness of the population.

    2. Segregational Load

    Definition: This type of load arises when different alleles (versions of a gene) exist at a single gene locus, and the heterozygote genotype has a higher fitness than either homozygote genotype.

    Impact: Even if natural selection favors the heterozygote, the homozygote individuals are still produced by sexual reproduction, resulting in some individuals with reduced fitness.

    3. Inbreeding Load

    Definition: Inbreeding load is the reduction in fitness that arises due to increased homozygosity (both alleles at a locus are identical) of deleterious recessive alleles. Inbreeding can lead to a greater expression of these harmful recessive traits.

    Impact: This is particularly a concern in small populations or those that are isolated, where genetic diversity is limited, and there is a higher chance of breeding between close relatives.

    REDUCING GENETIC LOAD

    Natural Selection and Genetic Drift

    Natural Selection: Over time, natural selection can reduce genetic load by favoring individuals with fewer harmful mutations. This selective pressure leads to a decrease in deleterious alleles in the gene pool.

    Genetic Drift: In small populations, genetic drift can also influence genetic load, sometimes increasing it by chance fixation of deleterious alleles or reducing it by chance elimination of such alleles.

    Artificial Selection and Genetic Management
    In managed populations, such as those in conservation programs or in agriculture, genetic load can sometimes be managed through selective breeding practices that aim to minimize the incidence of deleterious alleles while maintaining genetic diversity.

    Gene Editing
    With advances in genetic technologies like CRISPR/Cas9, there is potential to directly reduce genetic load by correcting deleterious mutations at the DNA level, although this approach is subject to ethical and practical considerations.

    Implications of Genetic Load
    Understanding and managing genetic load is crucial for the conservation of endangered species, the management of captive breeding programs, and understanding human health and disease. For example, genetic disorders in humans are often a direct manifestation of the genetic load, particularly when harmful recessive alleles become expressed in an individual’s genotype.

    Summary
    Genetic load is a significant evolutionary force that affects the fitness and viability of populations. Managing and understanding this concept is critical for improving health, conserving biodiversity, and understanding the evolutionary dynamics of populations.


    Source date (UTC): 2024-06-02 02:25:43 UTC

    Original post: https://twitter.com/i/web/status/1797092201366786048

  • MARS: MISSING MUSK’S POINT Like many, you miss Musk’s point, which is that the i

    MARS: MISSING MUSK’S POINT
    Like many, you miss Musk’s point, which is that the incremental solution to these problems by actually testing our ideas and discovering alternatives is the only way that we get to interstellar flight and the capacity for mankind to live independently of this planet and our solar system – both of which seem to attempt to exterminate us with disturbing regularity.
    In other words he’s not seeking mars for mars’ sake but mars as a step in the research and development program that brings us to the stars and evolutionary autonomy.
    And it’s not like anyone on earth makes better use of capital than he does in advancing technology, precisely because he uses this approach to innovation in advancement they way the Japanese do in refinement.
    We cant even get our government to worry about the next decade.

    Reply addressees: @LinusEkenstam


    Source date (UTC): 2024-05-28 23:55:40 UTC

    Original post: https://twitter.com/i/web/status/1795604887322951680

    Replying to: https://twitter.com/i/web/status/1795600846077731068

  • Correct Answer: 1) There isn’t code just supply demand and probability: The equi

    Correct Answer: 1) There isn’t code just supply demand and probability: The equilibrium between the environment, the cell’s homeostasis(demand), and the DNA (supply), where specialization of a cell is dependent upon the environment, which of course, consists of nearby cells and their inputs, outputs, whether chemical or charge. 2) it’s common understanding that the DNA consists of an inventory that is almost aways closed, and some section only opens when a demand string arrives and opens it. 3) The length of human DNA is constant over time. But modification can include mutation, rearrangement, number of copies, insertions and deletions (small), inversions, translocations, duplications, and then epigenetic variations in expression by variation in histones that carry the DNA strands, but they are only variations in expression. So, it’s a dance of supply and demand between the dna, the cell, other cells, and the environment they swim in. Just like we as humans do.

    Reply addressees: @PicoPaco17


    Source date (UTC): 2024-05-23 14:04:38 UTC

    Original post: https://twitter.com/i/web/status/1793644208311472128

    Replying to: https://twitter.com/i/web/status/1793083282827198585

  • Yes well, I really do love the man, and I advocate for him because of his use of

    Yes well, I really do love the man, and I advocate for him because of his use of representations (pictures, illustrations) rather than just pure mathematics, so he’s actually trying to produce a physical theory. But in this subject he’s just off the ranch so to speak. Because to say anything uses quantum effects is rather silly since everything uses quantum effects. On the other hand quantum effects are so small by the time we get to molecules that the consist of noise which is why we have stable (persistent) elements and molecules, and stable elements and molecules only interact with others who are stable as well. In the sense of microtubules transporting assets around cells that’s all they do other than provide structure – they have to do both or they can’t do the transport reliably. the fact that he got the idea from an anesthesiologist who got it from his mentor (another anesthesiologist) isn’t helping any. These people treat consciousness as ‘awareness’, and so they confuse the meaning of the term. (sigh)

    Reply addressees: @PaulBard73


    Source date (UTC): 2024-05-22 21:45:21 UTC

    Original post: https://twitter.com/i/web/status/1793397763394220032

    Replying to: https://twitter.com/i/web/status/1793395432498098527

  • SIR ROGER AND SILLY NONSENSE ABOUT MICROTUBULES IN CONSCIOUSNESS Microtubules. I

    SIR ROGER AND SILLY NONSENSE ABOUT MICROTUBULES IN CONSCIOUSNESS
    Microtubules. I wondered where Sir Roger Penrose got this ridiculous idea and now, well, now I know: anesthesiologist Stuart Hameroff.

    Simplicity: a microtubule functions like a rail, that motor proteins can carry ‘cargo’ (resources) along to transport whatever resources are necessary within the cell.

    In addition, because they are relatively strong, they can provide structure to keep organelles in place. In that way they are precursors to the evolution of veins, nerves, cartilage and bone, for similar purposes: structure and transport.

    So, in the context of anesthesia, inhibiting transport along microtubules will suppress electrochemical transmission.

    In particular, the axon hillock within the neuron, and the axon itself, is relatively dense with microtubules to ensure that the rather long distance of the axon (from neuron to nerve scales) can carry resources as neurons are expensive cells that must transmit over long distances.

    In this sense it is rather logical why we would concern ourselves with the role in suppressing consciousness by suppressing costly transmissions.

    But that role doesn’t tell us anything about how consciousness is produced. And how it’s produced is absurdly simple – just like all activity in the brain has turned out to be terribly simple (and as Neil Turok is thankfully finally advocating, that the laws of the universe are terribly simple).

    Cheers
    CD


    Source date (UTC): 2024-05-22 21:00:32 UTC

    Original post: https://twitter.com/i/web/status/1793386485611159553

  • Theology is dead. It’s left for just the weak. We had already passed through phi

    Theology is dead. It’s left for just the weak. We had already passed through philosophy. ANd now we live in a world of testifiability: science.

    You are done. Sorry. Time has left you behind. Just like genetics economics and political influence have left you behind.


    Source date (UTC): 2024-05-14 19:09:13 UTC

    Original post: https://twitter.com/i/web/status/1790459369038999675

    Reply addressees: @finishedyet34

    Replying to: https://twitter.com/i/web/status/1790445739039961212

  • Peer review is irrelevant. The only worthwhile criteria for a paper is its conte

    Peer review is irrelevant. The only worthwhile criteria for a paper is its contents though sometimes the lab or the academic suggests it’s worth a read. I deal with the mainstream sources everyone else does. Most papers are irrelevant, repetitions, or junk. But if you sift through them you do find the occasional useful effort. Never read any philosophy papers though. Not unless you want material for Dilbert comics. πŸ˜‰
    Cheers

    Reply addressees: @rightturnjason @NotWill42 @B1TCHEVAPORATE


    Source date (UTC): 2024-05-14 01:47:30 UTC

    Original post: https://twitter.com/i/web/status/1790197213382983680

    Replying to: https://twitter.com/i/web/status/1790195091048402986

  • There never has been anyone to state such a thing. It’s one of the most importan

    There never has been anyone to state such a thing. It’s one of the most important contributions I’ve made to the unification of the sciences.

    And yes, I agree, and hope, that ever school child should be taught this.

    And Affections to you both for recognizing it. πŸ˜‰


    Source date (UTC): 2024-05-07 04:11:26 UTC

    Original post: https://twitter.com/i/web/status/1787696720148635741

    Reply addressees: @orion_pulse @SenkoS8

    Replying to: https://twitter.com/i/web/status/1787696148213276866

  • PUBLIC DEMORALIZATION IN SCIENCE, ACADEMY, PUBLIC DISCOURSE, MEDIA, AND THE GOVE

    PUBLIC DEMORALIZATION IN SCIENCE, ACADEMY, PUBLIC DISCOURSE, MEDIA, AND THE GOVERNMENT.

    –“It’s disheartening to see how much influential science is crap and not reproducible.”–

    It is. But you know, I did a survey of ‘crank theories’ in physics about three years ago, and it turned out that one of them was rather obviously correct – at least as far as he had taken it – and I expect him to be vindicated at some point. “The universe really is that simple.”

    THE PROBLEM
    A byproduct of my work on testimony (which is technically what science consists of – the production of testifiable testimony) has led me to catalog human error, bias, deceit, and warfare in painful detail constructed from first principles (physical laws).

    IMO, from my research if we limited scientific publication and legitimacy(research), as well as reporting(media), a well as all members of the state and bureaucracy(government), to testifiable testimony (and I’m not going to cover it here, but it’s not that difficult) and held people liable for perjury on one hand, and institutions responsible for incentivizing perjury, then most of modern nonsense would disappear within the decade it took to build a body of case law, and it would both drastically reduce the population every field, rapidly increase it’s quality of output, rapidly increase compensation within the fields, and most importantly, at least in media, produce very wealthy individuals who were exceptional at providing the public with neutral information (instead of gossip, propaganda, sedition, and fraud).

    And the public would rather quickly, within a few years, restore trust in science, public intellectuals, media, and the government.

    Because that’s what trust consists of. Truth that accounts for the incentives of actors and the ends they seek to produce – most of which are false and impossible given that all ends are limited by demographic composition and geographic location.

    Curt Doolittle
    The Natural Law Institute

    Reply addressees: @Griffit15999943 @KirkegaardEmil @Shiftant


    Source date (UTC): 2024-05-06 23:39:45 UTC

    Original post: https://twitter.com/i/web/status/1787628346722959360

    Replying to: https://twitter.com/i/web/status/1787621836160970904