Is Population Structure in The Genetic Biobank Era Irrelevant, a Challenge, or An Opportunity? https://link.springer.com/article/10.1007/s00439-019-02014-8 Abstract Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously increases susceptibility of these methods to bias due to subtle population structure. Standard methods using genetic principal components to correct for structure might not always be appropriate and we use a simulation study to illustrate when correction might be ineffective for avoiding biases. New methods such as trans-ethnic modeling and chromosome painting allow for a richer understanding of the relationship between traits and population structure. We illustrate the arguments using real examples (stroke and educational attainment) and provide a more nuanced understanding of population structure, which is set to be revisited as a critical aspect of future analyses in genetic epidemiology. We also make simple recommendations for how problems can be avoided in the future. Our results have particular importance for the implementation of GWAS meta-analysis, for prediction of traits, and for causal inference.
Category: Human Behavior and Cognitive Science
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Is Population Structure in The Genetic Biobank Era Irrelevant, a Challenge, or A
Is Population Structure in The Genetic Biobank Era Irrelevant, a Challenge, or An Opportunity? https://link.springer.com/article/10.1007/s00439-019-02014-8 Abstract Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously increases susceptibility of these methods to bias due to subtle population structure. Standard methods using genetic principal components to correct for structure might not always be appropriate and we use a simulation study to illustrate when correction might be ineffective for avoiding biases. New methods such as trans-ethnic modeling and chromosome painting allow for a richer understanding of the relationship between traits and population structure. We illustrate the arguments using real examples (stroke and educational attainment) and provide a more nuanced understanding of population structure, which is set to be revisited as a critical aspect of future analyses in genetic epidemiology. We also make simple recommendations for how problems can be avoided in the future. Our results have particular importance for the implementation of GWAS meta-analysis, for prediction of traits, and for causal inference.
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The Wallet Game Is in Both Party’s Interest if You “buy” Within Your Means
The Wallet Game Is in Both Party’s Interest if You “buy” Within Your Means. https://propertarianism.com/2020/05/29/the-wallet-game-is-in-both-partys-interest-if-you-buy-within-your-means/
Source date (UTC): 2020-05-29 20:28:42 UTC
Original post: https://twitter.com/i/web/status/1266466520009408513
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The Wallet Game Is in Both Party’s Interest if You “buy” Within Your Means.
Mar 6, 2020, 9:37 AM
—“It’s the women who AREN’T looking to be supported who are often the most difficult. For … if they don’t need you for your financial support, that must mean they want you for emotional support. Which is a lot more complicated.”— by Michael Churchill
Be valuable: sexual, social, economic, political, military market value. This is as easy as (a) stay fit, (b) avoid risks to brain (drugs, alcohol), and fix broken brains (therapy, drugs, psychedelic treatments.) Live within the means of the value you create. Quality women will upgrade for consumption of stimulation at lower emotional, psychological, and compromise cost – men are not fulfilling masculine role for the given variability of woman’s demand for masculine traits. Quality men will upgrade for consumption of femininity at lower emotional, psychological, and compromise cost, given the invariability of the value of femininity to men. As we age our ability to learn, adapt, and compromise decreases – we demand greater consilience. Successful high school sweethearts from similar backgrounds with similar values working together to raise a family have least risk of divergence of consilience. Two Parent Working Families with Children in School create insufficient shared experience for relationship persistence. Our forecast of future value of one another is poor. Marriages currently operate via trade-ins for this reason. And while the cost of depreciation on a car is high; The cost of depreciation on marriage is far, far higher. This is why we must restore:
– Bring capital to people not people to capital – Civil Society so we are invested in the commons and one another. – Possibility of single parent income – Reduction or eliminate of 4 year high-debt education for all but extreme (outlier) cases. – Physical, emotional, and mental fitness by mindfulness training, physical fitness, and P-logic so that we have no deciets over the nature of man and what is possible for man.
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The Wallet Game Is in Both Party’s Interest if You “buy” Within Your Means.
Mar 6, 2020, 9:37 AM
—“It’s the women who AREN’T looking to be supported who are often the most difficult. For … if they don’t need you for your financial support, that must mean they want you for emotional support. Which is a lot more complicated.”— by Michael Churchill
Be valuable: sexual, social, economic, political, military market value. This is as easy as (a) stay fit, (b) avoid risks to brain (drugs, alcohol), and fix broken brains (therapy, drugs, psychedelic treatments.) Live within the means of the value you create. Quality women will upgrade for consumption of stimulation at lower emotional, psychological, and compromise cost – men are not fulfilling masculine role for the given variability of woman’s demand for masculine traits. Quality men will upgrade for consumption of femininity at lower emotional, psychological, and compromise cost, given the invariability of the value of femininity to men. As we age our ability to learn, adapt, and compromise decreases – we demand greater consilience. Successful high school sweethearts from similar backgrounds with similar values working together to raise a family have least risk of divergence of consilience. Two Parent Working Families with Children in School create insufficient shared experience for relationship persistence. Our forecast of future value of one another is poor. Marriages currently operate via trade-ins for this reason. And while the cost of depreciation on a car is high; The cost of depreciation on marriage is far, far higher. This is why we must restore:
– Bring capital to people not people to capital – Civil Society so we are invested in the commons and one another. – Possibility of single parent income – Reduction or eliminate of 4 year high-debt education for all but extreme (outlier) cases. – Physical, emotional, and mental fitness by mindfulness training, physical fitness, and P-logic so that we have no deciets over the nature of man and what is possible for man.
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History Solves the Incel Problem with Civil War
History Solves the Incel Problem with Civil War https://propertarianism.com/2020/05/29/history-solves-the-incel-problem-with-civil-war/
Source date (UTC): 2020-05-29 16:04:59 UTC
Original post: https://twitter.com/i/web/status/1266400153948299266
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History Solves the Incel Problem with Civil War
Mar 6, 2020, 4:40 PM
—“Curt, How do we solve the incel problem? Do we must accept as a natural fact that 80% of women go to 20% of men?”–
That’s not true. It’s that 30% of men are less desirable b/c they’ve been deprived of necessary male training, education, and fraternity in order to accomodate (the frailties of) women’s intolerance for dominance play. Yes, 1/3 of men are undesirable, but b/c dysgenia – fix both.
—“You mean we have 30% of good quality men who can’t find partner( marriage,children) because of feminist waves( freedom of women and its consequences).”—
I am saying that (a) people in general are having a lot less sex for reasons we understand, (b) women no longer need men for economic support or reproduction, ( c) incentives (education, taxes, immigration pressure) are hostile to marriage, (d) this is producing expected results. And yes, (e) the expected results mean that we have returned to the HISTORICAL NORM where 1/3 under monogamy, 2/3 under poverty, and as few as 1 in 17 men during prehistory have access to sex. These men are de facto, by the evidence, not of sufficient quality that women will defer other consumption in order to consume those men. Claiming they are of sufficient quality is simply demonstrably false. Fix men (product) or fix the incentives (market). Latter is easier. So – if you want to fix the problem fix men (product) fix incentives (markets). I suspect that incels are insufficiently manly to solve the problem as have their ancestors – and therefore are demonstrating the truth of the market condition. In other words, the gene pool is selecting incels out of it, unless incels demonstrate that they are manly enough not to be selected out of it.
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History Solves the Incel Problem with Civil War
Mar 6, 2020, 4:40 PM
—“Curt, How do we solve the incel problem? Do we must accept as a natural fact that 80% of women go to 20% of men?”–
That’s not true. It’s that 30% of men are less desirable b/c they’ve been deprived of necessary male training, education, and fraternity in order to accomodate (the frailties of) women’s intolerance for dominance play. Yes, 1/3 of men are undesirable, but b/c dysgenia – fix both.
—“You mean we have 30% of good quality men who can’t find partner( marriage,children) because of feminist waves( freedom of women and its consequences).”—
I am saying that (a) people in general are having a lot less sex for reasons we understand, (b) women no longer need men for economic support or reproduction, ( c) incentives (education, taxes, immigration pressure) are hostile to marriage, (d) this is producing expected results. And yes, (e) the expected results mean that we have returned to the HISTORICAL NORM where 1/3 under monogamy, 2/3 under poverty, and as few as 1 in 17 men during prehistory have access to sex. These men are de facto, by the evidence, not of sufficient quality that women will defer other consumption in order to consume those men. Claiming they are of sufficient quality is simply demonstrably false. Fix men (product) or fix the incentives (market). Latter is easier. So – if you want to fix the problem fix men (product) fix incentives (markets). I suspect that incels are insufficiently manly to solve the problem as have their ancestors – and therefore are demonstrating the truth of the market condition. In other words, the gene pool is selecting incels out of it, unless incels demonstrate that they are manly enough not to be selected out of it.
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Races
Mar 6, 2020, 5:09 PM Races aren’t smarter or dumber. Races, subraces, tribes, and clans have larger or smaller underclasses that shift the distribution downward, producing demand for norms at the median. The three exceptional peoples of modernity have merely culled their underclasses: Ashkenazi, Europeans, and East Asians by climate, farming, land provision, credit provision, war, disease, and prosecution of the undesirable. The question is why europeans are disproportionately more creative despite much smaller numbers, and this appears to be a combination of both genetic and civilizational causes.
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Europeans Are Soooo Much More Eccentric in Thought and Emotion and Variability and Width and Scale and Responsiveness.
Mar 6, 2020, 5:46 PM
—“I have to say … spending so much time in Latin America … when I come across pure European-blood people … it is an absolute shock. They are SOOOO much more eccentric in thought and emotion and variability and width and scale and responsiveness. It’s like an accordian. You are used to seeing it pressed in to its narrow form and then all the sudden you see it in its expanded form and it’s like wow! I didn’t know all these other dimensions existed. I have seen this so many times now … and it’s a perfect control experiment because these are people who have spent their entire lives in a Latin environment.”—Michael Churchill
Yep. It’s obvious. Unfortunately it’s a dunning kruger perception problem as well. It’s not possible for those who can’t sense perceive it to perceive it. In other words, you can’t observe it unless you’re part of it. So, how do we measure it so that we can prove it?