None really. But: 1. Relative Irreversibility. 2. B/C of 1, it’s not possible to

None really. But:
1. Relative Irreversibility.
2. B/C of 1, it’s not possible to warranty the consequences of genetic mutation – unless it’s a very simple (single) defect controlled by a single change.
3. We can measure mutation and ~expression but we can’t measure regulation.