Not sure I see the conflict:
–“Our results indicate that rare coding variants will implicate a tractable number of large-effect genes, that common and rare associations are mechanistically convergent, and that rare coding variants will contribute only modestly to missing heritability and population risk stratification.”-
vs
-“Our results imply that rare variants, in particular those in regions of low linkage disequilibrium, are a major source of the still missing heritability of complex traits and disease.”-
Plus testing for complex diseases versus height/body mass – even if H/BM is distributed it’s not the same as disease like schizophrenia. These results are what I’d expect.
But again, I’m happy to be wrong and be educated as a consequence.
Source date (UTC): 2023-02-21 20:14:25 UTC
Original post: https://twitter.com/i/web/status/1628126015481344000
Replying to: https://twitter.com/i/web/status/1628119545691996160
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